So I am going out on a limb and trying my hand at assembling my own "custom" Strat. I have a 57 Reissue body and now I am about to purchase a neck. Will a 2010 Am Standard C-neck, 22 frets with 4 mounting holes fit on the body? Any issues to look out for or any neck purchase tips? Thanks everyone!

It should fit. Only issue may be with the pickguard -- and it is pretty minor -- not sure if there are different ones for 22 fret vs 21 fret model guitars, but nothing a little sanding can't take care of.

It will fit with no issues,I have done it before.cheers

Fantastic. So you all think a 0.120 pickguard will fit instead of having to go down to a 0.090? I will head out to get some sandpaper. Thanks all and Happy New Year.