Is there a 'best' Strat for Southern rock? If so, why? And which (Fender) amp would you pair it with?

Probably just about any strat in the bridge/middle position.

Hook it up to a Twin Reverb. There's pretty much nothing that amp can't do.

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MIM Std Tele, MIM HSS Strat, Homemade Mongrel Tele, Blues Jr, Champ600, coupla pedals...sweeeet!

A good breakup sound , unless you want to go deaf.

I think the Texas Blues Strat HSS from a few years ago. That ought to fit the bill.

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Love my Telecaster, Stratocaster, and other guitars.

Very true. Or a pedal on it (which i love to avoid). Fender amps tend to always sound and feel muddy to me. I haven't seen a Fender amp yet that I can put mid gain on, palm mute some low string note, and hear anything but flub-flub-flub. I don't care how good everything else sound on them (and they do sound great), but that part is a total deal breaker for me.

Hey StratoCats-

Strat with Texas Specials and a HR Deluxe works for me-

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There's Always Room For MELLOW !!!!

2000 MIM Stratocaster, Midnight Wine W/Texas Specials
2000 Fender Hot Rod Deluxe
1969 Fender Vibro Champ

Buy a Fender Lonestar Strat. Texas Specials in Neck and Middle. Duncan Pearly Gates in Bridge. Run it to a 15w or higher tube amp, give it some gain. Now you have a rockin' guitar tone.

Those Lonestars were cool. I liked those better than the current Highway One's.