Since this is all subjective just like what are the best Strat pickups..Lets here what you all feel are the best Amp and guitar combos..Even though many say that Marshalls were made for gibsons i have always felt that the sound of a hot Strat and a JTM 45 was a great combination..Then if you were talking blues a Fender twin and a Strat gave some great tones also...What are favorite guitar amp combo's?

Gibson Les Paul and Marshall JTM45
Strat and Super Reverb
Rickenbacker 360-12 and Vox AC-30
Tele and a Deluxe Reverb

Strat and 59 Bassman ,even better than strat and super reverb IMHO

I'm lucky enough to have some great gear. After years searching for "the tone", I settled for "the toneS".

My main MIA strat with Hot Noiseless, "Sophi" and my Mesa Boogie Tremoverb. Pure Hard rock bliss.

My CS 50th '54 with my '57 Deluxe is the perfect early Fender tone.

My Tele Plus (or a Les Paul) with my Marshall JCM800, getts scorching metal!

if I'm feeling jazzy, I go with a strat and my Hot Rod Deluxe on the clean setting.

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SG.
"Walls" video from Zero in the Sun by Villains of Yesterday

Fender CS '56 Stratocaster + JMI (akaVOX) AC 15 for The Shadows tunes
Fender CS Cabonita + Fender '57 Champ for all non-clean sounds
T Anderson Crowdster + Fender Acoustasonic Pro for folk/pop rythm

Baja Tele and a couple of jcm 800's (very billy gibbons in the 4th position)
Clapton modded strat and a couple of jcm 800's (monster for metal rhythm, very scott ian)
57 hotrod and a couple of jcm 800's (good for anything)

Can you tell I like them JCM's.

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No no and no

Gibson Les Paul through an old Twin Reverb.
Strat through a Deluxe Reverb II.
Although I would like to try the strat through an old bassman or dual showman.
filerj

You'd like it. I do.

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The blues ain't nothin but a good man feelin bad.

I am very partial to my Gibby Explorer 1 (mohagany body/maple neck), my MIA standard Stratocaster (ash), and my BC Rich neck thru assassin through my 5150. I find it very versital to my needs. Then again, I am a metal head so that might explain it . Of course needs/likes vary person to person.


hotrod

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1983 Gibson Explorer 1 (main axe)
2004 Fender American Standard Stratocaster (Butterscotch on ash 1 piece maple neck and fretboard) (my baby)
2008 BC Rich Assassin neck thru(fun toy)
Peavey 5150 212 combo (early model) FREAKIN CRUNCH MONSTER!

The rig I have listed in my sig suits me awesome right now.

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Customized strat and a mesa boogie. Worked nicely for Santana, Roger Fisher of Heart (Magic Man, Barracuda), and Brad Gillis of (Ozzy, Night Ranger). That's what I have and I couldn't ask for a better sounding, more versatile rig.

A great guitarist with: A guitar and an amplifier, best combination ever

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Fender Highway One HSS Stratocaster '09
Modified Fender Champ600
Honer Special20 Harmonica

A Strat and this.

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The blues ain't nothin but a good man feelin bad.

A Telecaster and a Mesa/Boogie Mark I.

Or, perhaps, a Stratocaster and a Bassman.

Failing that, a Rickenbacker 360 and a Vox AC30.

Custom Shop Gilmour or Clapton and a CS 57 Twin Tweed.
Just for my musical liking. There are others for other people just as good!