If you tweak your sustain sound in your lead guitar set up just perfect enough, when you play lead a drug endorphin will start to release in your brain and give you joyful natural drug high. This is why Jimmy Hendrix always rolled his eyes around and about and looked drugged out, it was the endorphins which were released by the sound he created and loved.
The smooth sustaining highs and feedback also release this natural drug. A good valve amp can aid you in this search and experience. When the perfect sustain sound is achieved other phenomenon can start occuring such as more movement of the body and jumping around more. If you havent got a great set up just buying a little fuzz box can assist you in finding the natural high of the perfect sustain.

It is what it is....

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Being able to play and enjoy music is a gift that's often taken for granted.

Don't leave home without it!

Playing or listening to music can release endorphins and create a pleasurable feeling. Wow, how about that: music is pleasurable! But there's no "sustain = endorphins" effect. And I think we all know that Jimi was real high, alright, but not on sustain (next you'll be telling us that routine exposure to feedback makes your aspirate your own stomach contents).

Vinny I suspect Jimi looked drugged out because he was a notorious drug user!!

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I'm not an expert, but I play one on the internet.

Wash your moth out with soap twelvebar

And then there's the, "Brown Note" which gives you a joyous feeling of utter relief.

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You dig?

Ive heard about the brown note, its when you $@!& your pants on stage because youve stuffed up your bits and made a total fool of yourself hahahahhahahahahahahaahahahahahaha

What kind of soap Vinny, I don't wanna hurt the little guy.

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I'm not an expert, but I play one on the internet.

He is cute twelvebar and very fluffy

Try playing a guitar solo on an acoustic you just dont get the rolling eyes in your head effect do you ?

Looking forward to the next morsel of Vinnypop wisdom

Ah now endorphines and music is something i've recently been forced to explore to aid my smoking quit.
The simplified version is-
Addictive substances seize control of the brain and the first thing the majority of them do is control dopamine release. No dopamine = feel lousy all the time. Get a fix of whatever your addicted to be it coke, smack, nicotine or alcohol and your addiction rewards you with a dopamine rush. Which pretty much conns you into thinking that the substance makes you feel good.
Several medical persons familiar with addiction treatment told me that when you quit you need to spoil yourself rotten, basicaly to force your brain into releasing dopamine/endorphines without the addiction's say so. Listening to music you enjoy in a near perfect enviroment is pretty high up on my smoking cessation nurse list of endorphine releasing activities.

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No no and no

Buying guitars also releases endorphins.

I'm an endorphin donor. Mike

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The blues ain't nothin but a good man feelin bad.