Some frets seem to have less sustain than others, is uneven sustain between frets normal?

well i dont know the answer to your question, but ive noticed im lacking alot of sustain when i player higher notes for some reason, it could be my gear. its mostly set up for very high output pickups which are on my other guitars. i tried doing some tweaking on my effects board and amp but im not getting any better results

I wanted more sustain so I got a Boss Compression Sustainer. It gave me the sustain I was looking for along with a side affect I didn`t want, hum and static through the amp. I had to get a Noise Supressor to quiet it down. The higher frets don`t seem to hold the note as long which was why I got the effect pedal in the first place. Its like an addiction, one pedal leads to another.

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If your noticing a lack of sustain on upper frets it could be caused by the pickups being too high.
Uneven sustain across the fretboard could be a trussrod/action adjustment issue or a symptom of thr frets needing polishing. Thats a worst case scenario it could just be a setup issue. Its hard to tell without hands on examination.

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No no and no

I think it has more to do with the area of the neck, than the frets.

For instance, there's a natural "dead spot" right around the 10th fret. Trying fretting an F# on the A string and it usually won't sustain long on any guitar.

There's a more detailed, eloquent explanation of this, and I've read about it before (mainly regarding acoustic guitars) but I'm too lazy to look it up.

im thinkin mine might be a setup issue, this one i have is a loner untill i get mine so maybe ill mess with it a bit and see what happens, when i get mine ill have it set up right.

Dgonz, that also is another possibility. Sadly a lot harder to sort out than a fret polish. You may get somewhere by polishing the hell out of the neck but I think it would be very labour intensive for little reward. You could try a groovetubes fatfinger, its said to alleviate dead spots and improve sustain. I've got one i wasnt initially too impressed. the differences i noticed were minimal to negligible when i first put it on. When i took the fatfinger off then struck a open string and quickly put it against the headstock then took it off again i did hear a tonal difference. It enhances more than it alters. I use mine as a clamp to clamp a callaham sustain block onto the headstock of my tele now. All that extra mass does give a noticable difference.
It could be well worth you checking out, but be warned its effect is subtle.

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No no and no