I was thinking to myself the other day about the guitar's tone and came to the realization that I think that notes/chords played closer to the headstock sound richer/fuller and resonant differently from when they're played higher up on the fretboard. My theory goes like this: The higher up you go, the more percussive the note gets, the lower you get the more rich tone you will have. Tune one guitar standard and tune another a full step down D G C F A D and you can both play rich chord sequence of I, IV and V I think.

I noticed that I get a purer tone when I pick the string at the 2nd harmonic. For example if I fret at the 5th fret and pluck at the 17th it gives a purer tone.

It makes sense, at least intuitively, that the fundamental would be stronger when plucking at the half-way point.

When I want my melodies to sound sweeter I'll adjust my right hand position and try to stay closer to a midpoint between the bridge and fretted notes.

_________________
In my opinion Leo Fender had essentially perfected the guitar amplifier by 1964.