My live rig consists of the B52 AT-100 and Line 6 cab with cry baby wah and EB vol. I play my Gibson Explorer, 1989 Strat plus, 2001 Am Std, LTD F-400FM and LTD MH-301 the most. Occasionally I'll use my Ibanez RG7621 and Jaguar. The Jaguar is more for recording. I use the same stack for recording and also my Line 6 spider w/ the PODxt Live.

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Live guitars: 2009 LTD Truckster, 1989 Strat Plus, 2001 Am Standard Strat, 1996 MIJ Jaguar, 2007 Gibson Explorer 76 reissue, 1999 Ibanez RG7621, LTD MH-301, LTD FM400, 1999 Jackson Kelly, Mystery Les Paul, Hamer Chaparel, Fender FM 62SCE A/E Mandolin

my set up is pretty basic, that way not much can go wrong, also its nice to be appreciated for technique rather than being known for just effects. I do own a fair bit of stuff but my main rig is:

A fender Hot Rod Deluxe
Fender J5 Tele for Standard Tuning and drop D
Fender Jim Root Tele for open D and drop C
A Tech 21 Comptortion
A Tech 21 Killer Wail
Boss TU2
A power supply
PLanet Waves Cables

See my sig.

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Mostly playing mid 90's Grover Jackson era Washburn USA Chicago Custom guitars through a Fender Prosonic.
Here are a few of my Washys the mid 90's MG's

And my Prosonics
Tweeked combo converted to a 1/12



And the MONSTER a 100 watt prosonic head with reverb that was handbuilt by Zinky and given to Brad Whitford.

Strat, Les Paul or 6120 -> Stage Tuner -> Compressor -> OD -> another OD -> Delay/Echo -> A/B/Y -> A-Side into Fender 59 Bassman, B-Side into Korg/Vox AC30. I usually practice at home with a Fender Blues Junior.